Multiple Antigenic Peptide System

MAPS (Multiple Antigenic Peptide System)

MAPS is a method for producing high-titer anti-peptide antibodies (1,2) and synthetic peptide vaccines (3). This system utilizes the a- and e-amino functional groups of lysine to form a backbone to which multiple peptide chains are attached. Depending on the number of lysine tiers (2, 4, 8, etc.), different numbers of peptide branches can be synthesized. Using this new technology, our customers have successfully produced high-titer antibodies.

References:

	1. Wang, C. Y., Looney, D. J., Li, M. L., Walfield, A. M., Ye, J., Hosein, B., Tam, J. P. and Wong-Staal, F. "Long-term high-titer neutralizing activity induced by octameric synthetic HIV antigen" Science 254, 285-288 (1991).
	2. Posnett, D., McGrath, H., and Tam, J. P. "A novel method for producing anti-peptide antibodies" J. Biol. Chem. 263, 1719-1725 (1988).
	3. Tam, J. P. "Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system" PNAS USA 85, 5409-5413 (1988).