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Fluorescent Dyes  >  Fluorescent Biopolymers  >>  BTA-1

Product Name BTA - 1
[2 - (4'' - (methylamino)phenyl)benzothiazole]
Size 10 mg
Catalog # AS-88301
US$ $66
Description

BTA-1 is an uncharged derivative of thioflavin-T that has high a affinity for Ab fibrils and shows very good brain entry and clearance. The Kd of [3H]BTA-1 for binding to AD brain is very similar to the Kd for binding to synthetic Ab fibrils. BTA-1 does not appear to bind significantly to common neuroreceptors or transporter sites. BTA-1 exhibits high affinity for amyloid deposits (Ki = 11 nM for Ab(1-40)). It crosses the blood brain barrier and displays up to 50-fold higher affinity than ThT. It selectively stains cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C desiccated and protected from light
References Ishikawa K, et al. (2004). Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies. J Gen Virol 85, 1785-90. Klunk WE, et al. (2003). The binding of 2-(4
Molecular Weight 240.3
Spectral Properties Abs/Em = 350/NA nm
Solvent System DMSO
     
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