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Fluorescent Dyes  >  Fluorescent Biopolymers  >>  Chrysamine G

Product Name Chrysamine G
Size 10 mg
Catalog # 88303
US$ $66
Description

Chrysamine G (CG) is a carboxylic acid analogue of Congo red, a histologic dye which stains amyloid. CG binds to the b-amyloid protein of Alzheimer''s disease (AD) in vitro and partitions into the brain of normal mice. The binding of CG is correlated with numbers of senile plaques and neurofibrillary tangles. CG displays both high (Kd = 200 nM; Bmax = 1.13 moles per mole of Ab40) and low (Kd = 38.77 mM; Bmax = 23.10 moles per mole of Ab40) affinity binding sites for b-amyloid (Ab) fibrils. It can cross the blood-brain barrier and serve as an useful probe for detecting senile plaques (Ab aggregate). In addition, CG can be used to stain cerebrovascular amyloid in tissue sections.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C desiccated and protected from light
References Mathis CA, et al. (2004). Imaging b-amyloid plaques and neurofibrillary tangles in the aging human brain. Curr Pharm Des 10, 1469-92. Klunk WE, et al. (1998). Chrysamine-G, a lipophilic analogue of Congo red, inhibits A?-induced toxicity in PC12 cells. Life Sci 63, 1807-14. Klunk WE, et al. (1995). Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe. Neurobiol Aging 16, 541-8.
Molecular Weight 482.5
Spectral Properties Abs/Em = 386/NA nm
Solvent System DMSO
     
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