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Peptides  >  Gastrins  >>  Gastrin-1, human

Product Name Gastrin - 1, human
Size 1 mg
Catalog # AS-20750
US$ $127
Purity % Peak Area By HPLC ≥ 95%

Gastrin-1 is also referred to as Gastrin-17 or “Little Gastrin.” Secretion of gastrin is induced by food intake and causes the release of gastric acid in the stomach. Secreted by the G cells in the gastric mucosa, it is one of the major bioactive forms of gastrin found in tissue and plasma (the other bioactive form is Gastrin-34 or Big Gastrin - Cat# AS-20747). Both Gastrin-17 and Gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of Gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor. Binding of Gastrin to the CCK2/Gastrin receptors on parietal cells of the stomach causes them to secrete hydrochloric acid (HCl) and stimulates lectin-like protein Reg expression via activation of PKC and RhoA. Gastrin also plays a role in release of Histamine and Pepsinogen.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20°C
References Choudhury, A. et al. Hoppe-Seylers Z Physiol Chem 361, 1719 (1980)
Niederle, B. Wien Klin Wochenschr 119, 561 (2007), doi: 10.1007/s00508-007-0897-x.
O’Connor A. et. al. Digestive Dis 32, 186 (2014), doi: 10.1159/000357848
Dockray, G. et.al. Pflügers Archiv 449,344 (2005)
Bundgaard, JR et al. J Biol Chem 272, 21700 (1997), doi: 10.1074/jbc.272.35.21700
Yakabi, K. et al. World J Gastroenterol 14, 6334 (2008), doi: 10.3748/wjg.14.6334
Molecular Weight 2098.2
(One-Letter Code)
(Three-Letter Code)
Pyr - Gly - Pro - Trp - Leu - Glu - Glu - Glu - Glu - Glu - Ala - Tyr - Gly - Trp - Met - Asp - Phe - NH2
Product Citations Castillo, GM. et al. (2013). Omeprazole and PGC-formulated heparin binding epidermal growth factor normalizes fasting blood glucose and suppresses insulitis in multiple low dose Streptozotocin diabetes model. Pharm Res 30, 2843.
Takiyama, K. et al. (2009). A Phos-tag-based fluorescence resonance energy transfer system for the analysis of the dephosphorylation of phosphopeptides. Anal Biochem 388, 235. doi:10.1016/j.ab.2009.02.039.
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