This peptide is a known endogenous MC3R and MC4R antagonist and a powerful orexigenic peptide when infused centrally. It increases cortisol release and inhibits pulsatile LH release in monkey. AGRP, like NPY, may mediate the effect of a negative energy balance on the reproductive system by suppressing the GnRH pulse generator. AgRP (83-132) significantly increases prolactin mRNA expression level and prolactin accumulation.
Ref: Vulliemoz, NR. et al. Endocrinol. 146, 784 (2005); Langouche, L. et al. J. Neuroendocrinol. 16, 695 (2004); Yang, Y. et al. Mol. Endocrinol. 13, 148 (1999).
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