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| Product Name |
Annexin 1 (ANXA - 1, Ac 2 - 12) |
| Size |
1 mg |
| Catalog # |
60598-1 |
| US$ |
$95 |
| Molecular Weight |
1351.6 |
Sequence
(One-Letter Code) |
Ac-AMVSEFLKQAW |
Sequence
(Three-Letter Code) |
Ac - Ala - Met - Val - Ser - Glu - Phe - Leu - Lys - Gln - Ala - Trp - OH |
| Description |
This acetylated peptide is an amino-terminus fragment of Annexin 1 (ANXA1). ANXA1, previously referred to as lipocortin 1 or LC1, is a member of the annexin superfamily that has a potent leukocyte antimigratory activity. This fragment, as well as the full-length ANXA1 may significantly reduce polymorphonuclear leukocyte (PMN) influx in mice. ANXA1 and ANXA1 mimetics, such as Ac (2-12), inhibit recruitment of neutrophils in acute and chronic inflammation. This peptide is able to inhibit neutrophil extravasation. |
| References |
Ref: Perretti, M. et al. Nature Medicine 8, 1296 (2002); Mylinh, LA. et al. FASEB J. 15, 2247 (2001); Perretti, M. et al. Am. J. Pathol. 158, 1969 (2001); Lim, L. et al. Proc. Natl. Acad. Sci. USA 95, 14535 (1998). |
| Storage |
-20°C |
| Detailed Information |
 Material Safety Data Sheets (MSDS)
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