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Peptides  >  Angiotensins and Related Peptides  >>  Angiotensin I, human

Product Name Angiotensin I, human
DRVYIHPFHL
Size 25 mg
Catalog # 20628
US$ $121
Purity % Peak Area By HPLC ≥ 95%
Description

This human Angiotensin I (Ang I) sequence also corresponds to horse, sheep, pig, and rat Ang I. Ang I is cleaved to Ang II by the angiotensin-converting enzyme (ACE). There is also evidence for non-angiotensin-converting enzyme-dependent conversion of Ang I to Ang II. Human chymase efficiently converts the 10-mer Ang I to the 8-mer hormone Ang II by splitting the Phe8-His9 bond in Ang I.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Ref: Lundequist, A. et al. J. Biol. Chem. 279, 32339 (2004); Olson, S. et al. Am. J. Physiol. Lung. Cell Mol. Physiol. 287, L559 (2004); Sanker, S. et al. J. Biol. Chem. 272, 2963 (1997).
Molecular Weight 1296.5
Sequence
(One-Letter Code)
DRVYIHPFHL
Sequence
(Three-Letter Code)
H - Asp - Arg - Val - Tyr - Ile - His - Pro - Phe - His - Leu - OH
Product Citations Basile, F. et al. (2011). Rapid online nonenzymatic protein digestion combining microwave heating acid hydrolysis and electrochemical oxidation. Anal Chem 83, 359.
Zhang, C. et al. (2011). Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase–endothelial nitric oxide synthase pathway in rats. Clin Exp Pharmacol Physiol 38, 55.
Keppel, T. et al. (2009). The use of acetone as a substitute for acetonitrile in analysis of peptides by liquid chromatography/electrospray ionization mass spectrometry. Rapid Comm Mass Spectrom 24, 6.
Rauniyar, N. et al. (2009). Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography-tandem mass spectrometry using data-dependent acquisition: Neutral loss-driven MS3 versus neutral loss-driven electron capture dissociation. Anal Chem 81, 782.
     
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