Human salivary histatins (Hsts), which belong to a salivary polypeptide family, are small, cationic, histidine-rich proteins. They have potent bactericidal and antifungal activities against Candida albicans and Cryptococcus neoformans, and are therefore potential therapeutic reagents against Candida species.They kill fungal cells by binding to the cell membrane, internalizing, and disrupting volume regulatory mechanisms and mitochondrial function, leading to the production of reactive oxygen species and non-lytic loss.
Yoshida, M. et al. Biol. Pharm. Bull.24, 1267 (2001); Ahmad, M. et. al. J. Histochem. Cytochem.52, 361 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Lys - Phe - His - Glu - Lys - His - His - Ser - His - Arg - Gly - Tyr - OH