Login
Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Password:
Stay Logged In


Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Peptides  >  Saposin Related Peptides  >>  Prosaptide TX14(A)

Product Name Prosaptide TX14(A)
TaLIDNNATEEILY
Size 5 mg
Catalog # 60248-5
US$ $385
Purity % Peak Area By HPLC ≥ 95%
Description

This 14-mer prosaptide sequence is derived from the active neurotrophic region in the amino-terminal portion of the saposin C domain. Synthetic peptides derived from this region are biologically active and are named “prosaptides.” Prosaposin and prosaptides are active on a variety of neuronal cells, stimulating sulfatide synthesis and increasing sulfatide concentration in Schwann cells and oligodendrocytes. This indicates that prosaposin and prosaptides are trophic factors for myelin formation.

Detailed Information Datasheet
Storage -20°C
References Ref: Campana, M. et al. FASEB J. 12, 307 (1998); Hiraiwa, M. et al. Proc. Natl. Acad. Sci. USA 94, 4778 (1997); Taylor, E. et al. Pharmacol. 295, 190 (2000); Calcutt, NA. et al. Anesthesiology 93, 1271 (2000).
Molecular Weight 1579.7
Sequence
(One-Letter Code)
TaLIDNNATEEILY
Sequence
(Three-Letter Code)
H - Thr - D - Ala - Leu - Ile - Asp - Asn - Asn - Ala - Thr - Glu - Glu - Ile - Leu - Tyr - OH
Product Citations Meyer, R. et al. (2013). GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. PNAS 110, 9529. doi: 10.1073/pnas.1219004110.
Calcutt, NA. et al. (2000). Protection of sensory function and antihyperalgesic properties of a prosaposin-derived peptide in diabetic rats. Anesthesiology 93, 1271.
Otero, D. et al. (1999). Reversal of thermal hyperalgesia in a rat partial sciatic nerve ligation model by Prosaptide™ TX14(A). Neurosci Lett 270, 29.
Campana, WM. et al. (1998). Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 12, 307.
Hiraiwa, M. et al. (1997). Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. PNAS 94, 4778.
     
  < Back