Like neuropeptide Y (NPY) and other peptides of the family, this peptide adopts a folded hairpin structure with the terminal segments in close proximity. An intracerebroventricular injection of NPY or [Leu31, Pro34]-NPY (non-Y2 receptor agonist) given during middle cerebral artery occlusion increases the infarct volume and nitric oxide (NO) overproduction in the rat brain.
Ref: Futilendorf, I. et al. Proc. Natl. Acad. Sci. USA 87, 182 (1990). Khiat, AJ. Pept. Res. 51, 317 (1998); Chen, S. and RJ. Cheung, Biomed. Sci.12, 267 (2005); Chen, S. and RJ. Cheung, Biomed. Sci. 11, 781 (2004); Labelle, M. et al. Peptides 18, 801 (1997)
Molecular Weight
4240.8
Sequence (One-Letter Code)
YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY-NH2
Sequence (Three-Letter Code)
H - Tyr - Pro - Ser - Lys - Pro - Asp - Asn - Pro - Gly - Glu - Asp - Ala - Pro - Ala - Glu - Asp - Met - Ala - Arg - Tyr - Tyr - Ser - Ala - Leu - Arg - His - Tyr - Ile - Asn - Leu - Leu - Thr - Arg - Pro - Arg - Tyr - NH2
Datasheet
Material Safety Data Sheets (MSDS)
