This peptide, containing the consensus sequence XKYX(P/V)M, is found to stimulate phospholipase C (PLC)-mediated formation of InoPs in certain cell lines and human neutrophils. WKYMVm-NH2 may have the ability to activate the microbicidal functions of human neutrophils.
Ref: Baek, S. et al. J. Biol. Chem. 271, 8170 (1996); Boxio, R. et al. Scand. J. Immunol. 62, 140 (2005); Seo, J. et al. J. Immunol. 158, 1895 (1997) .