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Peptides  >  Thrombin Related Peptides  >>  Thrombin Receptor Activator for Peptide 6 (TRAP-6)

Product Name Thrombin Receptor Activator for Peptide 6 (TRAP - 6)
SFLLRN
Size 1 mg
Catalog # AS-24190
US$ $17
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide forms the N-terminal sequence left after thrombin cleavage of the receptor's amino-terminal exodomain thereby activating the thrombin receptor PAR1. This sequence then acts as a tethered peptide ligand. Free SFLLRN activates PAR1 independent of receptor cleavage and has been used to probe PAR1 function in various cells and tissues. This peptide is also known to be capable of activating PAR2.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References 1, Hammes, SR and Coughlin, SR. Biochem, 38:2486-2493 (1999).
2, Scarborough, RM. et al. J. Biol. Chem. 267, 13146 (1992).
3, Ahmad, S. and PN. Walsh, Biochem. 44, 13858 (2005).
4, Buergler, M. et al. J. Thromb. Thrombolysis 19, 115 (2005).
Molecular Weight 748.9
Sequence
(One-Letter Code)
SFLLRN
Sequence
(Three-Letter Code)
H - Ser - Phe - Leu - Leu - Arg - Asn - OH
Product Citations Birukova, A. et al. (2010). Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling . Transl Res 155, 44. doi:10.1016/j.trsl.2009.09.002.

Jenkins, R. et al. (2006). Ligation of protease-activated receptor 1 enhances αv β6 integrin–dependent TGF-β activation and promotes acute lung injury. J. Clin. Invest 116, 1606. doi:10.1172/JCI27183.

Ludeman, M. et al. (2005). PAR1 Cleavage and signaling in response to activated protein C and thrombin. J Biol Chem 280, 13122. doi:10.1074/jbc.M410381200

Birukova, AA. et al. (2004). Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J 18, 1879. doi: 10.1096/fj.04-2328com

Kawkitinarong, K. et al. (2004). Differential Regulation of human lung epithelial and endothelial barrier function by thrombin. Am. J. Respir. Cell. Mol. Biol 31(5), 517. doi:10.1165/rcmb.2003-0432OC

Ludeman, MJ. et al. (2004). Regulated shedding of PAR1 N-terminal exodomain from endothelial cells. J. Biol. Chem 279, 18592. doi: 10.1074/jbc.M310836200
     
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