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Peptides  >  Thrombin Related Peptides  >>  RGD-4C

Product Name RGD - 4C
ACDCRGDCFCG (Disulfide bridge: 2 - 10 and 4 - 8)
Size 5 mg
Catalog # AS-29898
US$ $1743
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide, a double cyclic peptide, binds preferentially to integrins at sites of tumor angiogenesis and inflammed synovium in-vivo, and can be internalized into targeted cells.

Detailed Information Datasheet
Storage -20C
References Ref: Curnis, F. et al. Cancer Res. 64, 565 (2004); Su, Z. et al. Bioconjug. Chem. 13, 561 (2002); Gerlag, M. et al. Arthritis Res. 3, 357 (2001); Ellerby, H. et al. Nature Med. 5, 1032 (1999);
Molecular Weight 1145.3
Sequence
(One-Letter Code)
ACDCRGDCFCG (Disulfide bridge: 2-10 and 4-8)
Sequence
(Three-Letter Code)
H - Ala - Cys - Asp - Cys - Arg - Gly - Asp - Cys - Phe - Cys - Gly - OH (Disulfide bridge: 2 - 10 and 4 - 8)
Product Citations Dane, K. et al. (2009). Cell surface profiling with peptide libraries yields ligand arrays that classify breast tumor subtypes. Mol Cancer Ther 8, 1312.
Wang, H. et al. Mol Cancer Ther 7, 1044 (2008).
Harui, A. et al. J Leukocyte Bio 79. 1271 (2006).
Kolonin, M. G. et al. Cancer Res 66, 34 (2006).
Line, B. R. et al. J Nucl Med 46, 1552 (2005).
Munt, N. et al. (2001). Solution Structures and Integrin Binding Activities of an RGD Peptide with Two Isomers. Bochem 40, 2373.
     
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