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Peptides  >  Toxins  >>  Charybdotoxin

Product Name Charybdotoxin
Pyr - FTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS (Disulfide bridge: 7 - 28, 13 - 33 and 17 - 35)
Size 0.1 mg
Catalog # 28244
US$ $171
Purity % Peak Area By HPLC ≥ 95%
Description

Charybdotoxin (ChTX) is a Ca2+-activated K+ channel blocker. It depolarizes peripheral T lymphocytes and blocks their mitogen-induced proliferation. ChTX is a highly basic peptide isolated from venom of the scorpion, Leiurus quinquestriatus hebraeus.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20C
References Ref: Leonard, R. et al. Proc. Natl. Acad. Sci. USA 89, 10094 (1992); Gimenez-Gallego, Proc. Natl. Acad. Sci. USA 85, 3329 (1988). Sugg, E. et al. J. Biol. Chem. 265, 18745 (1990).
Molecular Weight 4296
Sequence
(One-Letter Code)
Pyr-FTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS (Disulfide bridge: 7-28, 13-33 and 17-35)
Sequence
(Three-Letter Code)
Pyr - Phe - Thr - Asn - Val - Ser - Cys - Thr - Thr - Ser - Lys - Glu - Cys - Trp - Ser - Val - Cys - Gln - Arg - Leu - His - Asn - Thr - Ser - Arg - Gly - Lys - Cys - Met - Asn - Lys - Lys - Cys - Arg - Cys - Tyr - Ser - OH (Disulfide bridge: 7 - 28, 13 - 33 and 17 - 35)
Product Citations Welschoff, J. et al. (2014). RGD peptides induce relaxation of pulmonary arteries and airways via β3-integrins. FASEB J 28, 2281. doi: 10.1096/fj.13-246348.
Bayram, Z. et al. (2010). The role of nitric oxide and potassium channels in the effect of adrenomedullin in human internal thoracic arteries. Regul Pept 161, 92.
Sankaralingam, S. et al. (2008). Chronic clofibrate administration prevents salineinduced endothelial dysfunction and oxidative stress in young Sprague-Dawley rats. Clin Invest Med 31, e62.
Desai, KM. et al. (2006). EDHF-mediated rapid restoration of hypotensive response to acetylcholine after chronic, but not acute, nitric oxide synthase inhibition in rats. Eur J Pharmacol 546, 120.
     
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