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Peptides  >  Toxins  >>  Chlorotoxin (Cltx)

Product Name Chlorotoxin (Cltx)
MCMPCFTTDHQMARKCDDCCGGKGRGKCYGPQCLCR - NH2 (Disulfide bridge: 2 - 19,5 - 28,16 - 33,20 - 35)
Size 0.1 mg
Catalog # 60770
US$ $115
Purity % Peak Area By HPLC ≥ 95%
Description

A 36-amino acid Cl- channel blocker from Leiurus quinquestriatus scorpion venom.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20C
References Ref: DeBin, JA. and GR. Strichartz, Toxicon 29, 1403 (1991); DeBin, JA. et al. Am. J. Physiol. 264, C361 (1993).
Molecular Weight 3996
Sequence
(One-Letter Code)
MCMPCFTTDHQMARKCDDCCGGKGRGKCYGPQCLCR-NH2 (Disulfide bridge: 2-19,5-28,16-33,20-35)
Sequence
(Three-Letter Code)
H - Met - Cys - Met - Pro - Cys - Phe - Thr - Thr - Asp - His - Gln - Met - Ala - Arg - Lys - Cys - Asp - Asp - Cys - Cys - Gly - Gly - Lys - Gly - Arg - Gly - Lys - Cys - Tyr - Gly - Pro - Gln - Cys - Leu - Cys - Arg - NH2 (Disulfide bridge: 2 - 19,5 - 28,16 - 33,20 - 35)
Product Citations El-Ghlban, S. et al. (2014). Chlorotoxin-Fc fusion inhibits release of MMP-2 from pancreatic cancer cells. BioMed Res Intl 2014.
Kovar, JL. et al. (2013). Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors. Anal Biochem 440, 212. doi: 10.1016/j.ab.2013.05.013.
Wan, J. et al. (2010). Incorporation of magnetite nanoparticle clusters in fluorescent silica nanoparticles for high-performance brain tumor delineation. Nanotechnololgy 21, 235104.
Orndorff, RL. and SJ. Rosenthal. (2009) Neurotoxin quantum dot conjugates detect endogenous targets expressed in live cancer cells. Nano Lett 9, 2589. doi: 10.1021/nl900789e.
Jing, M. and W. Cai. (2007). Specific targeting of gliomas with multifunctional superparamagnetic iron oxide nanoparticle optical and magnetic resonance imaging contrast agents. Acta Pharmacol Sinica 28, 2019. doi: 10.1111/j.1745-7254.2007.00661.x.
Meng, XX. et al. (2007). Specific targeting of gliomas with multifunctional superparamagnetic iron oxide nanoparticle optical and magnetic resonance imaging contrast agents. Acta Pharmacol Sinica 28, 2019.
     
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