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Peptides  >  Neurotensins and Related Peptides  >>  Neurotensin (8-13)

Product Name Neurotensin (8 - 13)
Size 5 mg
Catalog # AS-22964
US$ $71
Purity % Peak Area By HPLC ≥ 95%

The intrastriatal perfusion with the neurotensin(1-13) [NT(1-13)] and its active fragment NT(8-13) on striatopallidal GABA leads to the increased striatal and pallidal GABA release, and this effect is antagonized by intrastriatal perfusion with the NT receptor antagonist. In other experiments, NT, NT (8-13) and [D-Tyr(11)] NT are applied into the ventral tegmental area on extracellular dopamine in the prefrontal cortex and nucleus accumbens of rats. In the prefrontal cortex, neurotensin(8-13) is as potent as neurotensin but ineffective in [D-Tyr(11)]neurotensin. In the caudal nucleus accumbens, neurotensin(8-13) and neurotensin appears more potent than [D-Tyr(11)]neurotensin. In contrast, in the rostral nucleus accumbens, neurotensin(8-13) is less potent than [D-Tyr(11)]neurotensin and neurotensin.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Ref: Sotty, F. et al. Neurosci. 98, 485 (2000); Ferraro, L. et al. Eur. J. Neurosci. 9, 1838 (1997); Gao, G. and E. Wei, J. Pharmacol. Exp. Ther. 265, 619 (1993).
Molecular Weight 817
(One-Letter Code)
(Three-Letter Code)
H - Arg - Arg - Pro - Tyr - Ile - Leu - OH
Product Citations Milovnik, P. et al. (2009). Selection and characterization of DARPins specific for the neurotensin receptor 1. Protein Eng. Des. Sel. 22, 357.
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