The intrastriatal perfusion with the neurotensin(1-13) [NT(1-13)] and its active fragment NT(8-13) on striatopallidal GABA leads to the increased striatal and pallidal GABA release, and this effect is antagonized by intrastriatal perfusion with the NT receptor antagonist. In other experiments, NT, NT (8-13) and [D-Tyr(11)] NT are applied into the ventral tegmental area on extracellular dopamine in the prefrontal cortex and nucleus accumbens of rats. In the prefrontal cortex, neurotensin(8-13) is as potent as neurotensin but ineffective in [D-Tyr(11)]neurotensin. In the caudal nucleus accumbens, neurotensin(8-13) and neurotensin appears more potent than [D-Tyr(11)]neurotensin. In contrast, in the rostral nucleus accumbens, neurotensin(8-13) is less potent than [D-Tyr(11)]neurotensin and neurotensin.
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References
Ref: Sotty, F. et al. Neurosci. 98, 485 (2000); Ferraro, L. et al. Eur. J. Neurosci. 9, 1838 (1997); Gao, G. and E. Wei, J. Pharmacol. Exp. Ther. 265, 619 (1993).
