This decapeptide is a hypothalamic hormone that controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the pituitary gland and promotes mating behavior. It stimulates the secretion of gonadotropins after its interaction with specific G-protein-coupled receptors that are present in plasma membranes of pituitary gonadotrophs. In addition to hypophysiotropic effect, it also plays a autocrine/paracrine role in peripheral organs such as prostate, breast and ovary. Luteinizing hormone-releasing hormone is not only a neurohormone but may also function as a neurotransmitter or neuromodulator.
Kiss, J. and B. Halasz, Neurosci14, 69 (1985); Zheng, L. et al. Neurosci46, 407 (1992); Collado, B. et al. Intl J Oncol24, 725 (2004); Hoffman, G. et al. Brain Res 2005 Aug 5; [Epub ahead of print]; Wang, V. et al. Am J Obstet Gynecol160, 984 (1989).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Pyr - His - Trp - Ser - Tyr - Gly - Leu - Arg - Pro - Gly - NH2