Melan-A is a melanocyte differentiation antigen recognized by cytotoxic T lymphocytes. This sequence is a naturally presented Melan-A/MART-1 nonamer peptide. The Melan-A/MART-1 gene is expressed by normal melanocytes, as well as by most fresh melanoma samples and melanoma cell lines. This peptide appears to be a very common immunogenic epitope for HLA-A2-restricted melanoma-specific tumor-infiltrating lymphocytes (TIL) and may be useful for the development of immunotherapeutic strategies.
Ref: Kawakami, Y. et al. J. Exp. Med 180, 347 (1994); Schneider, J. et al. Int. J. Cancer 75, 451 (1998).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Ala - Gly - Ile - Gly - Ile - Leu - Thr - Val - OH