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Peptides  >  Pituitary Adenylate Cyclase Activating Peptides (PACAPS)  >>  PACAP (1-27), amide, human, ovine, rat

Product Name PACAP (1 - 27), amide, human, ovine, rat
HSDGIFTDSYSRYRKQMAVKKYLAAVL - NH2
Size 1 mg
Catalog # 22528
US$ $231
Purity % Peak Area By HPLC ≥ 95%
Description

PACAP-27, the N-terminal fragment of PACAP-38, is a neuropeptide originally isolated from bovine hypothalamus, but is also found in humans and rats. It shows considerable homology with Vasoactive Intestinal Polypeptide (VIP), but stimulates adenylate cyclase much more potently than VIP. PACAP27 and PACAP38 stimulate cAMP accumulation and increase [Ca2+]i through the type I PACAP receptors.

Storage -20C
References Ref: Miyata, A. et al. BBRC 164, 567(1998); Chik, C. et al. J. Neurochem. 67, 1005 (1996).
Molecular Weight 3147.7
Sequence
(One-Letter Code)
HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2
Sequence
(Three-Letter Code)
H - His - Ser - Asp - Gly - Ile - Phe - Thr - Asp - Ser - Tyr - Ser - Arg - Tyr - Arg - Lys - Gln - Met - Ala - Val - Lys - Lys - Tyr - Leu - Ala - Ala - Val - Leu - NH2
Product Citations Kidane, A. et al. (2008). Pituitary adenylate cyclase-activating polypeptide regulates brain-derived neurotrophic factor exon IV expression through the VPAC1 receptor in the amphibian melanotrope cell. Endocrin. 149, 4177.
Kidane, A. et al. (2007). Actions of PACAP and VIP on melanotrope cells of Xenopus laevis. Peptides 28, 1790.
Wu, K. et al. (2006). Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nat Neurosci 9, 1257.
     
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