This peptide is a specific substrate of PKA, catalytic subunit and is phosphorylated by PKA. It contains P-2 and P-6 arginines that can be used to assess the roles of Tyr-204 and Glu-203. The peptide has a structure similar to typical Arg-X-X-Arg-Arg-X-Ser-X phosphorylation site sequence in substrates of cAMP dependent protein kinase .
Ref: Zhou , J. and JA. Adams, Biochem. 36, 15733 (1997); Yoo, D. et al. J. Biol. Chem. 278, 23066 (2003); Glass, DB. J. Biol. Chem. 264, 8801 (1989); Moore, M. et al. J. Biol. Chem. 278, 10613 (2003); He, B. and G. Weber, Eur. J. Biochem. 270, 2174 ( 2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Arg - Thr - Gly - Arg - Arg - Asn - Ser - Ile - OH