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Peptides  >  Cancer Research Peptides  >>  VEGFR2/KDR Antagonist

Product Name VEGFR2/KDR Antagonist
ATWLPPR
Size 1 mg
Catalog # AS-60628
US$ $127
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is a specific VEGFR2/KDR heptapeptide antagonist, it binds VEGFR2 (KDR/flk), completely inhibiting VEGF binding to KDR and preventing VEGF-induced angiogenesis in-vivo. It specifically inhibits human endothelial cell proliferation in-vitro and totally abolishes VEGF-induced angiogenesis in-vivo.

Storage -20C
References Ref: Renno, R. et al. Invest. Ophthalmol. Vis. Sci. 43, 3977 (2002); Brekken, R. et al. Cancer Res. 60, 5117 (2000); Jia, H. et al. J. Biol. Chem. 279, 36148 (2004); Ye, F. Gynecol. Oncol. 94, 125 (2004); Bin?truy-Tournaire, R. et al. EMBO J. 19, 1525 (2000).
Molecular Weight 840
Sequence
(One-Letter Code)
ATWLPPR
Sequence
(Three-Letter Code)
H - Ala - Thr - Trp - Leu - Pro - Pro - Arg - OH
Product Citations Renno, RZ. et al. (2004). Selective photodynamic therapy by targeted Verteporfin delivery to experimental choroidal neovascularization mediated by a homing peptide to vascular endothelial growth factor receptor-2. Arch Ophthalmol 122, 1002. doi:10.1001/archopht.122.7.1002.
Liu, H, et al. (2013). Hyperoxia causes regression of vitreous neovascularization by downregulating VEGF/VEGFR2 pathway. Invest Ophthalmol Vis Sci 54, 918. doi: 10.1167/iovs.12-11291.
     
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