This 27-residue peptide, designated MPGΔNLS,is derived from the hydrophobic fusion peptide of HIV-1 gp41 (for efficient crossing of the cell membrane) and the hydrophilic nuclear localization sequence of SV40 large T antigen (for the nuclear addressing of the peptide). MPGΔNLS contains a single mutation in which the second lysine in the NLS has been mutated to serine.
Deshayes, S. et al. Adv. Drug Deliv. Rev. 60, 537 (2008); Morris, M. et al. Nucleic Acids Res. 27, 3510 (1999); Simeoni, F. et al. Nucleic Acids Res. 31, 2717 (2003).
Molecular Weight
2766.2
Sequence (One-Letter Code)
GALFLGFLGAAGSTMGAWSQPKSKRKV
Sequence (Three-Letter Code)
H - Gly - Ala - Leu - Phe - Leu - Gly - Phe - Leu - Gly - Ala - Ala - Gly - Ser - Thr - Met - Gly - Ala - Trp - Ser - Gln - Pro - Lys - Ser - Lys - Arg - Lys - Val - OH
Datasheet
Material Safety Data Sheets (MSDS)
