This DPDPE peptide is an opioid receptor agonist. The striatal dopamine release induced by this peptide probably depends on glutamate release from corticostriatal glutamatergic afferents in response to the stimulation of d-opioid receptors located on terminals of these neurons.
Ref: Strassheim, D. et al. Mol. Pharmacol. 53, 1047 (1998); Froimowitz, M. Biopolymers 30,1011 (1990); McFadyen, et al. Pharmacol. 295, 960 (2000); Fusa, K. et al. Neurosci. 30, 745 (2005); Billet, F. et al. Eur. J. Neurosci. 20, 2629 (2004); Browning, K. et al. J. Neurosci. 24, 7344 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Tyr - D - Pen - Gly - Phe - D - Pen - OH (Disulfide bridge: 2 - 5)