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Peptides  >  Fibronectin Fragments  >>  Fibrinolysis Inhibiting Factor

Product Name Fibrinolysis Inhibiting Factor
GPRP
Size 5 mg
Catalog # AS-24262
US$ $99
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide mimics the N terminus of the alpha-chain of fibrin. It binds to the 'a' polymerization pocket in the alpha-chain more tightly than a peptide corresponding to the chain native sequence GPRV. The complex between GPRP and fibrinogen causes an increased resistance to degradation by plasmin, and the polymerization reaction is depressed by the addition of excess peptide. Fibrin assembly, as well as the acceleration of the factor XIIIa reaction, can be prevented by this homologue of the natural sequence of amino acids.

Detailed Information Datasheet
Storage -20C
References Ref: Pratt, K. et al. Proc. Natl. Acad. Sci. USA 94, 7176 (1997); Lorand, L. et al. Proc. Natl. Acad. Sci. USA 95, 537 (1998).
Molecular Weight 425.5
Sequence
(One-Letter Code)
GPRP
Sequence
(Three-Letter Code)
H - Gly - Pro - Arg - Pro - OH
Product Citations Johnson, C. et al. (2010). Biocompatibility Assessment of the First Generation PediaFlow Pediatric Ventricular Assist Device. Artificial Organs doi:10.1111/j.1525-1594.2010.01023.x.
     
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