A hypotensive and diuretic peptide. Originally isolated from the skin of the frog, Phyllomedusa sauvagei. It affects diuresis in the cardiovascular system and causes the release of ACTH and endorphins.
Ref: Montecucchi, PC. et al. Int. J. Pept. Protein Res. 20, 139 (1982); Erspamer, V. et al. Trends Pharmacol. Sci. 20, 391 (1980).
Molecular Weight
4599.4
Sequence (One-Letter Code)
Pyr-GPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2
Sequence (Three-Letter Code)
Pyr - Gly - Pro - Pro - Ile - Ser - Ile - Asp - Leu - Ser - Leu - Glu - Leu - Leu - Arg - Lys - Met - Ile - - Glu - Ile - Glu - Lys - Gln - Glu - Lys - Glu - Lys - Gln - Gln - Ala - Ala - Asn - Asn - Arg - Leu - Leu - Leu - Asp - Thr - Ile - NH2