Members of the ARF family are subjected to myristoylation at the N-terminal glycine residue, a lipid co-translational modification that appears essential for functional activity. This myristoylated ARF-6 is a strong inhibitor of calcium-evoked catecholamine secretion and phospholipase D activation in chromaffin cells, the non-myristoylated ARF-6 (cat# 60782) and the myristolated ARF-1 (cat# 60781) have mimimal effects.
Ref: Galas, M-C. et al. J. Biol. Chem. 272, 2788 (1997); Donaldson, JG. and RD. Klausner, Curr. Opin. Cell Biol. 6, 527 (1994); Matsukawa, J. et al. J. Biol. Chem. 278, 36470 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Myr - Gly - Lys - Val - Leu - Ser - Lys - Ile - Phe - Gly - Asn - Lys - Glu - OH