Login
Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Password:
Stay Logged In


Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Assay Kits  >  Viral/Bacterial Protease Assay Kits - HIV, HCV, TEV, WNV, Sortase  >>  HCV NS3/4A protease mutant D168A, recombinant

Product Name HCV NS3/4A protease mutant D168A, recombinant
Size 10 g
Catalog # 72032-10
US$ $379
Description

The Hepatitis C Virus (HCV) NS3/4A serine protease is essential for viral replication and the formation of infectious viral particles, and thus has been considered as one of the most attractive targets for anti-HCV therapy. Due to poor fidelity of viral reverse transcriptase and RNA-dependent RNA polymerase, drug resistant mutations emerge rapidly against protease inhibitors. The mutant D168A has been identified to confer the resistance to a potent protease inhibitor, BILN 2061.

The recombinant HCV NS3/4A protease mutant D168A is derived from its wild type (NCBI Accession: CAB46913) with a substitution of Asp168 with Ala. It is a 217 amino acid fusion protein with NS3 protease domain and a fragment of the NS4A protein fused to its N-terminus.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -80C
     
  < Back