This sequence is the hallmark of MUC1 mucin. MUC1 is a highly glycosylated type I transmembrane glycoprotein with a unique extracellular domain consisting of a variable number of tandem repeats (VNTR) of this 20 amino acid peptide It is overexpressed on the cell surface of many human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma, making MUC1 broadly applicable target for immunotherapeutic strategies
Storage
-20°C
References
Ref:: Brossart, P. et al. Blood 93, 4309 (1999); Wajchman, H. et al. Cancer Res 64, 1171 (2004)
Molecular Weight
1887
Sequence (One-Letter Code)
PDTRPAPGSTAPPAHGVTSA
Sequence (Three-Letter Code)
Pro - Asp - Thr - Arg - Pro - Ala - Pro - Gly - Ser - Thr - Ala - Pro - Pro - Ala - His - Gly - Val - Thr - Ser - Ala
