|
|
|
|
|
| Product Name |
Protease - Activated Receptor - 1, PAR - 1 Agonist |
| Size |
1 mg |
| Catalog # |
61530 |
| US$ |
$55 |
| Molecular Weight |
762.9 |
Sequence
(One-Letter Code) |
TFLLRN |
Sequence
(Three-Letter Code) |
H - Thr - Phe - Leu - Leu - Arg - Asn - OH |
| Description |
This protease-activated receptor-1 (PAR-1) selective peptide induces cyclooxygenase-2 (COX-2) protein and mRNA expression in human endothelial cells. Studies show that intratracheal instillation of the PAR1-specific peptide increases lung edema during high-tidal-volume ventilation
|
| References |
Ref: Syeda,, F. et al. J. Biol. Chem 281, 11792 (2006); Jenkins, R. et al. J. Clin. Invest; 116, 1606 (2006). |
| Storage |
-20°C |
| Detailed Information |
 Product Information
 Material Safety Data Sheets (MSDS)
|
| Product Citations |
Firth, AL. et al. (2009). Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 296, L979.
Wilson, TJ. et al. (2009). Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1.Cancer Res. 69, 3188.
Jenkins, RG. et al. (2006). Ligation of protease-activated receptor 1 enhances αv β6 integrin–dependent TGF-β activation and promotes acute lung injury J. Clin. Invest. 116, 1606.
Rauch, BH. et al. (2004). Thrombin and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells. Circ. Res. 94, 340.
Kataoka, H. et al. (2003). Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood 102, 3224.
|
|
|
|
|
|
|
