This peptide, derived from the BH3 domain of Bak (Flu-BakBH3), has been shown to have high-affinity binding to a surface pocket of the Bcl-XL protein that is essential for its death antagonist function.
Wang, J. et al. Cancer Res.60, 1498 (2000); Juin, P. et al. Mol. Cell. Biol. 2, 6158 (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Gln - Val - Gly - Arg - Gln - Leu - Ala - Ile - Ile - Gly - Asp - Asp - Ile - Asn - Arg - OH