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Peptides  >  FRET Peptides  >>  Malaria Aspartyl Proteinase FRET Substrate I

Product Name Malaria Aspartyl Proteinase FRET Substrate I
[DABCYL - Glu - Arg - Nle - Phe - Leu - Ser - Phe - Pro - EDANS]
Size 5 mg
Catalog # AS-24481
US$ $869
Description

A useful fluorogenic substrate for the continuous assay of malaria aspartyl proteinase.

Minimum Purity: 95%

Detailed Information Datasheet
Storage -20°C desiccated and protected from light
References Flotow H, et al. (2002). Development of a plasmepsin II fluorescence polarization assay suitable for high throughput antimalarial drug discovery. J Biomol Screen 7, 367-71.
Molecular Weight 1507.5
Spectral Properties Abs/Em = 355/500 nm
Solvent System water
Product Citations Azim, M. et al. (2008). Identification of acridinyl hydrazides as potent aspartic protease inhibitors. Bioorg Med Chem Lett 18, 3011.
Kim, YM. et al. (2006). Prodomain processing of recombinant plasmapepsin II and iv, the aspartic proteases of Plasmodium falciparum, is auto-and trans catalytic J. Biochem. (Tokyo) 139, 189.
Johansson, P-O. et al. (2004). Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs. J. Med. Chem. 47, 3353.
Nöteberg, D. et al. (2003). Design and synthesis of plasmepsin I and II Inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes. J. Med. Chem. 46, 734.
     
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