First MAGE CTL epitope mapped, it is the HLA-A1-restricted MAGE-1 peptide. Human melanoma cells can process the MAGE-1 gene product and present tit on their major histocompatibility complex class I molecules, HLA-A1, as a determinant for cytolytic T lymphocytes (CTLs).
Luescher, I. et al. J. Biol. Chem. 271, 12463 (1996); Mukherji, B. et al. PNAS 92, 8078 (1995).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Glu - Ala - Asp - Pro - Thr - Gly - His - Ser - Tyr - OH