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Peptides  >  Protein Phosphorylation Related Peptides  >>  Insulin B (9-23)

Product Name Insulin B (9 - 23)
SHLVEALYLVCGERG
Size 1 mg
Catalog # AS-61532
US$ $115
Purity % Peak Area By HPLC ≥ 95%
Description

This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.

Detailed Information Datasheet
Storage -20C
References Devendra, D. et al. Diabetes 54, 2549 (2005). Starwalt, S. et al. Protein Eng. 16, 147 (2003); Lee, L. et al. PNAS 102, 15995 (2005).
Molecular Weight 1645.9
Sequence
(One-Letter Code)
SHLVEALYLVCGERG
Sequence
(Three-Letter Code)
H - Ser - His - Leu - Val - Glu - Ala - Leu - Tyr - Leu - Val - Cys - Gly - Glu - Arg - Gly - OH
Product Citations Alam, S. et al. (2010). Enhanced trafficking to the pancreatic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal B lymphocytes in non-obese diabetic mice. Diabetologia 53, 346.
Alam, C. et al. (2010). Inflammatory Tendencies and overproduction of IL-17 in the colon of young NOD mice are counteracted with diet change. Diabetes 59, 2237.
Kang, Y. et al. (2008). Cutting Edge: Immunosuppressant as adjuvant for tolerogenic immunization. J Immunol 180, 5172.
     
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