C-terminal fragments of the Alzheimer Aß peptide (amino acids 29-40 and 29-42) have physical and chemical properties related to those of the fusion peptides of viral proteins. These peptides are able to induce the fusion of liposomes in-vitro. 29 to 40 and 29 to 42 domains of the Aß peptide can be critical for the amyloid-apoE interaction and can play a protective role against the formation of Aß aggregates and/or against their interaction with cellular membranes.
Ref: Pillot, T. et al. Eur. J. Biochem. 243, 650 (1997); Gaskin, F. J. Exp. Med. 177, 1181 (1993).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - OH