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Peptides  >  Cancer Research Peptides  >>  Bid BH3-R9

Product Name Bid BH3 - R9
RRRRRRRRRGEDIIRNIARHLAQVGDSMDR
Size 1 mg
Catalog # 61713
US$ $231
Purity % Peak Area By HPLC ≥ 95%
Description

Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of the BCL-2 family proteins that constitute a critical control point in apoptosis. BID BH3 interacts with Bax to induce mitochondrial outer membrane permeabilization in the apoptotic process. This peptide contains 9 Arg residues in the L-isomeric form on the N-terminus. BID Tagging with poly-arginine facilitates cell internalization.

Storage -20C
References Letai, A. J Clin Invest 115, 2648 (2005). Mendoza, F. et al. Arch Immunol Ther Exp 53, 47 (2002).
Molecular Weight 3772.3
Sequence
(One-Letter Code)
RRRRRRRRRGEDIIRNIARHLAQVGDSMDR
Sequence
(Three-Letter Code)
H - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Gly - Glu - Asp - Ile - Ile - Arg - Asn - Ile - Ala - Arg - His - Leu - Ala - Gln - Val - Gly - Asp - Ser - Met - Asp - Arg - OH
Product Citations Siskind, L. et al. (2010). The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during Apoptosis. J Biol Chem 285, 11818.
     
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