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Peptides  >  Cancer Research Peptides  >>  Bid BH3-r8

Product Name Bid BH3 - r8
rrrrrrrr - GEDIIRNIARHLAQVGDSMDR
Size 0.5 mg
Catalog # 61715
US$ $363
Purity % Peak Area By HPLC ≥ 95%
Description

The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.

Storage -20C
References Letai, A. J.Clin. Invest. 115, 2648 (2005); Mendoza, F. et al. Arch. Immunol. Ther. Exp. 53, 47 (2002).
Molecular Weight 3616.2
Sequence
(One-Letter Code)
rrrrrrrr-GEDIIRNIARHLAQVGDSMDR
Sequence
(Three-Letter Code)
H - D - Arg - D - Arg - D - Arg - D - Arg - D - Arg - D - Arg - D - Arg - D - Arg - Gly - Glu - Asp - Ile - Ile - Arg - Asn - Ile - Ala - Arg - His - Leu - Ala - Gln - Val - Gly - Asp - Ser - Met - Asp - Arg
     
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