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Peptides  >  Protein Phosphorylation Related Peptides  >>  Cathepsin D and E FRET Substrate

Product Name Cathepsin D and E FRET Substrate
Mca - GKPILFFRLK(Dnp) - r - NH2
Size 1 mg
Catalog # 61793
US$ $143
Purity % Peak Area By HPLC ≥ 95%
Description

An internally quenched fluorogenic substrate (Ab/Em =328/393 nm) for cathepsins D and E and not for B, H or L, obtained from the hepatopancreas (liver) of the Japanese common squid (Todarodes pacificus). The cleavage occurs at the Phe-Phe amide bond resulting in enhanced fluorescence and is used in screening cathepsin D and E inhibitors and for determining cathepsin D and E activity in tissue cell extracts.

Storage -20C
References Yasuda, Y. et al. J. Biochem. 125, 1137 (1999).
Molecular Weight 1756.1
Sequence
(One-Letter Code)
Mca-GKPILFFRLK(Dnp)-r-NH2
Sequence
(Three-Letter Code)
7 - Methoxycoumarin - 4 - Acetyl - Gly - Lys - Pro - Ile - Leu - Phe - Phe - Arg - Leu - Lys(Dnp) - D - Arg - NH2
     
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