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Peptides  >  FRET Peptides  >>  390 MMP FRET Substrate I

Product Name 390 MMP FRET Substrate I
Mca - PLGL - Dpa - AR - NH2
Size 1 mg
Catalog # AS-27076
US$ $99
Purity % Peak Area By HPLC ≥ 95%
Description

A fluorogenic substrate that is best cleaved by MMP-7, 8, 9 and 13. The highly fluorescent Mca moiety is efficiently quenched by energy transfer to the Dnp group. The punctuated metallo proteinase (PUMP, EC 3.4.24.23) cleaves the substrate at the Gly-Leu bond with a 190-fold increase in fluorescence (Abs/Em = 325/393 nm). In human matrix metalloproteinases assays, this substrate is about 50 to 100 times more sensitive than the generic MMP substrate, Dnp-PLGLWAr-NH2 (Cat# 27074).

Detailed Information Datasheet
Storage -20C
References Ref: Knight, CG. et al. FEBS Lett. 296, 263 (1992); Netzel-Arnett, S. et al. Anal. Biochem. 195, 86 (1991).
Molecular Weight 1093.2
Sequence
(One-Letter Code)
Mca-PLGL-Dap(Dnp)-AR-NH2
Sequence
(Three-Letter Code)
Mca - Pro - Leu - Gly - Leu - Dap(Dnp) - Ala - Arg - NH2
     
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