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Peptides  >  Cancer Research Peptides  >>  Bid BH3 Peptide

Product Name Bid BH3 Peptide
EDIIRNIARHLAQVGDSMDR
Size 1 mg
Catalog # AS-61711
US$ $121
Purity % Peak Area By HPLC ≥ 95%
Description

BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.

Storage -20C
References Oh, K. J. et al J. Biol. Chem. 280, 753 (2005); Oh, K. J. et al. J. Biol. Chem. 281, 36999 (2006); Manero, F. et al. Cancer Res. 66, 2757 (2006); Zhai, D. et al. J. Biol. Chem. 280, 15815 (2005); Walensky, L. et al. Mol. Cell. 24, 199 (2006); Onuki, R. et al. Proc. Natl. Acad. Sci. U S A 99, 14716 (2002); Wang, K. Gen. Develop. 10, 2859 (1996).
Molecular Weight 2309.6
Sequence
(One-Letter Code)
EDIIRNIARHLAQVGDSMDR
Sequence
(Three-Letter Code)
H - Glu - Asp - Ile - Ile - Arg - Asn - Ile - Ala - Arg - His - Leu - Ala - Gln - Val - Gly - Asp - Ser - Met - Asp - Arg - OH
Product Citations Chipuk, J. et al. (2008). Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. PNAS 105, 20327.
Vaugh, AE. et al. (2008). Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nature Cell Biol. 10, 1477.
     
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