This peptide belongs to the RFamide family of peptides having similar C termini, P(L/Q)RF-NH2. The anti-opiate neuropeptides FF and AF (NPFF and NPAF) have been implicated in pain modulation as well as in opioid tolerance and may play a critical role in this process.
Kubiak,T. et al. J. Biol. Chem. 278: 42115 (2003); Elshourbagy, N et al. J. Biol. Chem., 275, 25965 (2000).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Gly - Glu - Gly - Leu - Asn - Ser - Gln - Phe - Trp - Ser - Leu - Ala - Ala - Pro - Gln - Arg - Phe - NH2