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Peptides  >  FRET Peptides  >>  HCV (Hepatitis C Virus) NS3/4A Protease Substrate

Product Name HCV (Hepatitis C Virus) NS3/4A Protease Substrate
Ac - DE - Dap(QXL 520) - EE - Abu - ψ - [COO]AS - C(5 - FAMsp) - NH2
Size 1 mg
Catalog # AS-60798
US$ $726
Purity % Peak Area By HPLC ≥ 95%
Description

A highly sensitive FRET substrate for assaying HCV (Hepatitis C Virus) NS3/4A protease activity. It detects < 0.1pmol of HCV NS3/4A protease. Upon cleavage of this substrate, fluorescence can be monitored at Abs/Em = 490/512 nm.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Poster
Storage -20C
References Ref: Tong, XH. et al. Understanding Biology Using Peptides. Sylvie E. Blondelle(Editor): American Peptide Society(2005); Tang, Y. et al. Viral Hepatitis Meeting Abstract (2005).
Molecular Weight 1913.8
Sequence
(One-Letter Code)
Ac-DE-Dap(QXL520)-EE-Abu-ψ-[COO]AS-C(5-FAMsp)-NH2
Sequence
(Three-Letter Code)
Ac - Asp - Glu - Dap(QXL520) - Glu - Glu - Abu - ψ - [COO] - Ala - Ser - Cys(5 - FAMsp) - NH2
Product Citations Yu, X. et al. (2012). Identification of hepatitis C virus inhibitors targeting different aspects of infection using a cell-based assay. Antimicrob Agents Chemother, 56, 6109.
Yu, X. et al. (2009). Development of a cell-based hepatitis C virus (HCV) infection FRET assay for high throughput antiviral compound screening. Antimicrob Agents Chemo doi:10.1128/AAC.00495-09.
Seiwert, S. et al. (2008). Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227). Antimicrob Agents Chemother 52, 4432.
     
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