H - Leu - Leu - Lys - Ala - Lys - Leu - Thr - Asp - Pro - Lys - Glu - Asp - OH
Description
This peptide is a functional nuclear export signal (NES) that plays a major role in the localization of Dok1. Dok1 is an adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. Dok-1 shuttles between the nucleus and cytoplasm. The expulsion from the nucleus generally depends upon NES sequence, a short leucine-rich motif that is specifically recognized by the nuclear exporter protein known as chromosomal region maintenance 1 (CRM1).
