Activity-dependent neurotrophic factor (ADNF) is a nine amino acid peptide originally purified from conditioned medium of astrocytes. ADNF protects neurons from death induced by beta-Amyloid at extremely low concentrations.
Chiba, T. et al. J. Neurosci. 25, 10252 (2005); D.Brenneman and I.Gozes J. Clin. Invest. 97, 2299 (1996).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Ala - Leu - Leu - Arg - Ser - Ile - Pro - Ala - OH