This peptide is derived from the tandem repeat of Muc 2 mucin protein. MUC2 is characterized by tandem and irregular repeat sequences rich in threonine and serine, the potential sites of attachment of the oligosaccharide chains. The primary function of the MUC2 gene product is to provide a protective barrier between the epithelial surfaces and the gut lumen. There is decreased expression of MUC2 in colonic cancer and defective polymerization of secreted mucin in ulcerative colitis. Mucins play a protective role for the adjoining epithelial tissues under normal physiological conditions, whereas an altered expression of mucins is often associated with carcinomas and neoplastic lesions.
Lesuffleur, T. et al. J. Biol. Chem. 270, 13665 (1995); Singh, A. et al. Cancer Res. 64, 622 (2004); Allen, A. et al. Int. J. Biochem. Cell Biol. 30, 797 (1998).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Pro - Thr - Thr - Thr - Pro - Ile - Ser - Thr - Thr - Thr - Val - Thr - Pro - Thr - Pro - Thr - Pro - Thr - Gly - Thr - Gln - Thr - OH