This peptide is derived from the tandem repeat of Muc 3 mucin protein. MUC3 is a membrane associated mucin of the small intestine. Probiotic microbes induce MUC3 mucin transcription and translation with extracellular secretion of the MUC3 mucins. Mucins are highly O-glycosylated proteins which polymerize through the formation of disulfide bonds to form a gel that is secreted onto the surface of glandular epithelia. Mucins play a protective role for the adjoining epithelial tissues under normal physiological conditions; whereas an altered expression of mucins is often associated with carcinomas and neoplastic lesions.
Lesuffleur, T. et al. J. Biol. Chem. 270, 13665 (1995); Singh, A. et al. Cancer Res. 64, 622 (2004); Mack, D. et al. Gut 52, 827(2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - His - Ser - Thr - Pro - Ser - Phe - Thr - Ser - Ser - Ile - Thr - Thr - Thr - Glu - Thr - Thr - Ser - OH