Substance P (SP) is an important neuropeptide that has been implicated in several physiological processes. This SP fragment 8 to 11 amino acids was used in the healing of corneal epithelial wounds study. The combination of FGLM-NH2 and IGF-1 promotes corneal epithelial wound healing in diabetic rats, suggesting that this kind of treatment might prove effective in humans with diabetic keratopathy. Administration of eyedrops containing both FGLM–NH2 and SSSR is effective for the treatment of persistent epithelial defects in individuals with neurotrophic keratopathy.
Nakamura, M. et al. Diabetologia 46, 839 (2003); Yamada, et al. Invest. Ophthalmol. Vis. Sci. 47, 5018 (2006).