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Peptides  >  Amyloid Peptides  >  Humanins  >>  Colivelin

Product Name Colivelin
SALLRSIPAPAGASRLLLLTGEIDLP
Size 1 mg
Catalog # AS-61930
US$ $203
Purity % Peak Area By HPLC ≥ 95%
Description

This hybrid peptide named colivelin was synthesized to potentiate the neuroprotective effect of humanin (HN). Colivelin is composed of Activity-Dependent Neurotrophic Factor (ADNF) C-terminally fused to AGA-(C8R) HNG17, a potent HN derivative. Colivelin completely suppresses cell death induced by overexpressed Familial Alzheimer's disease (FAD)-causative genes and beta-amyloid (1-43). Intraperitoneally administered colivelin suppresses memory impairment and might serve as a novel drug candidate for treatment of Alzheimer's disease.

Storage -20C
References Chiba, T. et al. J. Neurosci. 25, 10252 (2005).
Molecular Weight 2645.1
Sequence
(One-Letter Code)
SALLRSIPAPAGASRLLLLTGEIDLP
Sequence
(Three-Letter Code)
H - Ser - Ala - Leu - Leu - Arg - Ser - Ile - Pro - Ala - Pro - Ala - Gly - Ala - Ser - Arg - Leu - Leu - Leu - Leu - Thr - Gly - Glu - Ile - Asp - Leu - Pro - OH
     
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