This is a humanin (HN) peptide analog where Ser14 is substituted with a D-isomer Ser. The D-isomerization at this position increases the HN neuronal rescue function from Alzheimer's disease-relevant insults by two to three orders of magnitude. Please see the related peptide, Humanin, cat # 60886.
Terashita, K. et al. J. Neurochem. 85, 1521 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Met - Ala - Pro - Arg - Gly - Phe - Ser - Cys - Leu - Leu - Leu - Leu - Thr - D - Ser - Glu - Ile - Asp - Leu - Pro - Val - Lys - Arg - Arg - Ala - OH