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Peptides  >  Signal Transduction Peptides  >>  Pannexin-1 (Panx1), Mimetic Blocking Peptide

Product Name Pannexin - 1 (Panx1), Mimetic Blocking Peptide
WRQAAFVDSY
Size 1 mg
Catalog # AS-61911
US$ $71
Purity % Peak Area By HPLC ≥ 95%
Description

This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1? (IL-1?) in response to P2X7R activation.

Detailed Information Datasheet
Storage -20C
References Pelegrin, P. et al. EMBO. J. 25, 5071 (2006); Pelegrin, P. et al.t J. Biol. Chem. 282, 2386 (2007).
Molecular Weight 1242.4
Sequence
(One-Letter Code)
WRQAAFVDSY
Sequence
(Three-Letter Code)
H - Trp - Arg - Gln - Ala - Ala - Phe - Val - Asp - Ser - Tyr - OH
Product Citations Karpuk, N. et al. (2011). Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity. J Neurosci 31, 414.
     
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