This amyloid precursor protein fragment amino acid residues 667 to 676 is a beta secretase substrate. This peptide may be also cleaved by Beta-site APP cleavage enzyme (BACE) between Met and Asp residues, and by the enzyme thimet oligopeptidase (TOP).
Koike, H. et al. J. Biochem. 126, 235 (1999); Grüninger-Leitch, F. et al. J. Biol. Chem. 277, 4687 (2002);
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Glu - Val - Lys - Met - Asp - Ala - Glu - Phe - Arg - OH